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A clear dose-response PK relationship was established over the entire range of lingual spray doses studied, as evidenced by the area-under-the-curve (AUC), The maximum serum concentration (Cmax) achieved by the lingual spray at each dose level was also dose-proportional. PC-SPES (spes means "hope" in Latin) has shown success in alleviating symptoms of benign prostatic hypertrophy and even advanced prostate cancer.

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Differences in pharmacodynamic effects were still statistically significant at 60 minutes post-dosing. The normal dose of coumadin is between 1 and 10 milligrams. 8% for the oral tablet; the difference is statistically significant).